Abstract :Ulcerative Colitis (UC) is an inflammatory chronic disease primarily affecting the colonic mucosa; the extent and severity of colon involvement are variable. In its most limited form, it may be restricted to the distal rectum, while in its most extended form, the entire colon is involved. UC belongs to the Inflammatory Bowel Diseases (IBD), which is a general term for a group of chronic inflammatory disorders of unknown etiology involving the gastrointestinal tract. UC is usually associated with recurrent attacks with complete remission of symptoms in the interim. The commonly used drugs for UC are sulfasalazine, mesalamine,olsalazide, balsalazide, budesonide, etc.